SmartFreez CELL Bottom-Up Controlled Rate Freezing System

CELL by SMARTFREEZ is an advanced controlled rate cryopreservation system designed to improve post thaw cell viability and functional recovery through a patented bottom-up freezing approach. Its directional heat transfer geometry minimizes natural convection and reduces supercooling by initiating ice formation in a small sacrificial layer before promoting uniform upward crystal growth. This controlled ice-nucleation and growth pattern lowers mechanical stress, decreases cryo concentration effects, and supports higher survival rates with reduced DMSO exposure. With programmable multi step methods, adjustable cooling rates up to 5°C per minute, integrated data export and visualization, and Digital Twin compatibility through SMARTFREEZSIM®, CELL enables Quality by Design optimization for reproducible and efficient cryopreservation workflows.

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Capacity: 1 holder for 48 x 2mL vials; 1 holder for 3 x 30mL bags
Dimensions (DxWxH): 18.11" x 14.17" x 23.6" (460mm x 360mm x 600mm)
Temperature range: -85 ºC to 25 ºC
Weight (lbs): 88
Patent status: Patented

Patented Bottom Up Freezing Technology
Directional heat transfer geometry promotes uniform upward ice growth to minimize mechanical stress and cryoconcentration.
Precise Ice Nucleation Control
Limits supercooling by restricting it to a small sacrificial layer, reducing uncontrolled crystal formation.
Controlled Crystal Growth
Regulates ice growth velocity and direction to improve post thaw cell viability and functional recovery.
Reduced Cryoprotectant Requirements
Supports high survival rates with lower DMSO concentrations.
Customizable Multi Step Protocols
Program up to 16 automated method steps for tailored cryopreservation workflows.
Adjustable Cooling Rates
Temperature ramp rates up to 5°C per minute for flexible experimental design.
Wide Operating Temperature Range
-85°C to 25°C to accommodate diverse cryopreservation applications.
Integrated Data Export and Logging
Download complete experiment datasets for in depth analysis and documentation.
Real Time Data Visualization
On screen overview of temperature profiles and process performance.
Intuitive Touchscreen Interface
User friendly digital display for rapid setup and operation.
Digital Twin Compatibility
Seamless integration with SMARTFREEZSIM® for protocol simulation, optimization, and predictive modeling.
Optimized Capacity Design
Holds one rack of 48 x 2 mL vials within a compact benchtop footprint.
Quality by Design Workflow Support
Enables rational protocol development with reduced trial and error and improved reproducibility.